---
title: Annotation
date: 2026-02-05T11:09:00+01:00
author: admin
canonical_url: "https://dlhycovid.sk/en/anotacia"
section: Univerzálne stránky
---
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# Annotation

 

 ![bg](/assets/images/universal/hero-bg.png) ![bg](/assets/images/universal/hero-bg.png) 

 

  COVID-19 is a viral infectious disease caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many millions of SARS-CoV-2 infection survivors, including both adults and children, live with chronic, systemic, and often disabling conditions commonly known as long COVID (LC). LC denotes a collection of long-term health consequences caused by the infection. The impact of LC is not limited to the health and quality of life of individual patients. Owing to its prevalence and the breadth of its clinical manifestations, it represents a major public health crisis; it strains health systems and national economies and threatens progress in global health, including the Sustainable Development Goals. Extensive literature supports the association between infection and cardiovascular (CV) complications, as well as an increased CV risk following infection. Endothelial dysfunction (ED) is a central pathomechanism in acute COVID-19 and has also been identified as a key pathogenic mechanism in the pathogenesis of LC. A growing number of studies highlight the significance of erythrocyte (Ery) abnormalities, abnormal clotting processes, excessive inflammation, and oxidative stress (OS) in LC patients. Different biomarker profiles may be associated with the variations in the clinical presentation (LC symptoms) and may suggest distinct pathomechanisms that are dominant in different patient subgroups. Although significant progress has been made in recent years in characterizing LC, many questions remain unanswered. Therefore, further studies and data are needed to develop effective and personalized therapeutic and preventive strategies. It is expected that the implementation of this project will contribute to elucidating the complex interplay between endothelial cells and Ery, the underlying pathomechanisms of ED in LC, and various aspects of the relationship between endothelial integrity changes, inflammation, OS, and hypercoagulable states.

 

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